The aim of study to fi nd out the effect on haematological and biochemical parameters following administration of propofol alone

and in-combinaiton with buprenorphine. Propofol was given to effect in group I (control), whereas buprenorphine @ 0.015 mg/kg b.wt. was given as preanaesthetic before propofol “to effect” in dogs of group II .Atropine sulphate was injected I/M @ 0.04 mg/kg b.wt. 20 minutes prior to each treatment in both the groups.Hb, PCV and TEC showed a signifi cant fall (P<0.05) at initial intervals of observation as compared to base line whereas, other haematological parameters were non-signifi cantly variables at different intervals of observation in both the groups.A non signifi cant alteration in the level of total serum protein, alkaline phosphatase activity, serum creatinine and blood urea nitrogen could be recorded at different observation periods either within the group or among the groups. There was signifi cant increase in serum glucose level at 1hr in both treatment groups followed by a progressive decrease in its value which reached to pretreatment value within 24hrs. There was signifi cant increase (P<0.05) in AST value at 1hr in group Iwhereas in group II, it could be recorded at hr 1 and 2 of observation.A signifi cant elevation (P<0.05) in ALT value could be recorded in both groups of animals at hr1 and 2 of observation as compared to their respective baseline value.It is concluded that propofol alone and in combination with buprenorphine produced no deleterious effect on the vital organs, hence can be used safely in dogs.